Antibiotics of the tetracycline series, which include Doxycycline, have a broad spectrum of action. This semi-synthetic antibiotic has a bacteriostatic effect on microorganisms - it suppresses microbes' ability to multiply in the body. The antibiotic penetrates the cells of microorganisms and blocks protein synthesis there. Doxycycline affects many microbes - pathogens of aerobic (requiring oxygen for development) and anaerobic (can develop without oxygen access) infections. Streptococci and staphylococci, Escherichia coli and Salmonella, dysentery bacillus, Klebsiella and Clostridia, causative agents of especially dangerous infections (cholera, plague, anthrax, and tularemia), sexually transmitted infections (syphilis, gonorrhea, chlamydia) are sensitive to Doxycycline.
The wide spectrum of action of the drug is especially important in cases where the disease's causative agent could not be identified for one reason or another. And some conditions, such as pneumonia, can be caused by various microorganisms. Doxycycline has no effect on fungi and viruses. When taken orally, the Doxycycline is almost completely absorbed in the stomach. Food intake has no effect on drug absorption.
It is impossible to say that Doxycycline is the best drug for any disease because the choice of an antibiotic depends on the pathogen and its sensitivity, and on the severity of the disease, and on the presence of concomitant pathology in the patient, and sometimes on the patient's financial capabilities.
Indications for use Doxycycline
The drug Doxycycline is prescribed to patients for the treatment of the following pathologies:
- Inflammatory and infectious diseases of the respiratory system - bronchitis (acute and chronic), pneumonia, bronchopneumonia, tracheitis, laryngitis, empyema of the lung, lung abscess;
- Infectious processes of the nasal and oropharyngeal organs - pharyngitis, otitis media, tonsillitis, sinusitis, sinusitis;
- Inflammatory diseases of the genitourinary system of infectious origin - pyelonephritis, cystitis, urethritis, gonorrhea, orchitis, epididymitis, urogenital mycoplasmosis, cervicitis, endocervicitis;
- Exacerbation of chronic cholecystitis;
- Infectious lesions of soft tissues - boils, carbuncles, abscesses, phlegmon, panaritium, the addition of a secondary bacterial infection in burns and wounds;
- Syphilis, proctitis, prostatitis, chlamydia.
The drug Doxycycline is also prescribed for prophylactic purposes after undergoing surgical interventions or traveling to countries where it is easy to become infected with listeriosis, dysentery, and cholera.
Contraindications for use Doxycycline
Doxycycline can only be taken as directed by your doctor. Before starting therapy, the patient should carefully read the attached instructions, since the medicine has the following contraindications for use:
- Individual intolerance to the components of the drug;
- The presence in the past of severe allergic reactions to drugs from the tetracyclines group;
- Lactose intolerance;
- Lactase deficiency;
- Age under 12;
- Severe violations of liver and kidney function;
- The patient's body weight is less than 45 kg.
Method of administration and dose of the drug
Doxycycline capsules are intended for oral administration. The drug Doxycycline is taken half an hour before meals without opening, drinking plenty of water. The daily dose of the medicine and the duration of the treatment course largely depends on the diagnosis, the severity of the clinical manifestations of the disease, the presence of complications, the patient's body weight, and the individual characteristics of the organism.
According to the instructions, the drug Doxycycline is prescribed 1 capsule 1 time per day for 3-5 days. In rare cases, the course of therapy can be extended to 7-10 days under a physician's supervision.
Patients with impaired liver function require an individual selection of the daily dose. Use of the drug during pregnancy and lactation
Doxycycline capsules are not indicated for the treatment of pregnant women. The active substance of the pills easily penetrates the placenta to the fetus and causes severe malformations of the skeleton, organs of the hematopoietic system, and the liver.
If a woman has taken the drug Doxycycline and she has a pregnancy, she should contact your gynecologist as soon as possible and tell him about the therapy you have received. In some cases, this pregnancy must be terminated.
The use of the drug during the period of breastfeeding is prohibited since the active substance of the capsules penetrates into breast milk and can cause disturbances in the functioning of the child's internal organs. If necessary, drug therapy is recommended to stop lactation.
Side effects usually develop with the appointment of high doses of the drug and a long treatment course.
- Stomach ache.
- Nausea, rarely vomiting.
- Diarrhea or constipation.
- Discomfort in the esophagus, burning of the tongue.
- Itchy skin, allergic rash.
- Darkening of tooth enamel in children.
- Photosensitivity (hypersensitivity of the skin to ultraviolet light).
Side effects cause changes in peripheral blood: anemia (hemolysis), neutropenia, thrombocytopenia, eosinophilia, azotemia. Identification of unwanted symptoms requires discontinuation of the drug.
Interaction with other medicinal products
The absorption of Doxycycline is reduced by antacids, iron preparations, laxatives, colestipol, and colestyramine. With the simultaneous appointment of drugs, it is necessary to observe a time interval of at least 3 hours. Do not use a drug with bactericidal antibiotics due to its antagonistic effect. Prescribing with anticoagulants requires adjusting the latter's dosage in connection with a decrease in the prothrombin index. Concomitant use with methoxyflurane leads to severe renal failure.
Doxycycline reduces the effectiveness of oral contraceptives. During Doxycycline treatment, it is necessary to also protect yourself through barrier contraception.
In its antimicrobial action, the drug surpasses the effect of natural antibiotics of the tetracycline group.
Unlike other medicines, the long-term therapeutic effect of the agent is maintained when using small doses.
Doesn't affect the gut microbiome as much. The use of this medication is less likely to cause complications associated with a violation of microflora.
Cross-resistance with other drugs of similar action from the group of penicillins and tetracyclines is possible.