The drug Amoxil is an antibiotic drug of a wide range of effects, which is characterized by an antibacterial effect that spreads to gram-negative and gram-positive pathological microorganisms. The drug is intended for use in the treatment of infectious diseases of various localization. The drug has fairly low toxicity, but it is characterized by a good therapeutic effect. This makes it possible to use a pharmacological agent in pediatric practice with the least negative consequences for a developing child's body.
The drug Amoxil's pharmacological action is an antibiotic from the aminopenicillin group, a wide spectrum of action of which allows you to quickly obtain a high bactericidal effect. The synthesis of cellular structures of pathogens is reduced, due to which the development of the virus stops, and the life cycle stops. After oral administration, the drug's active substance is almost completely absorbed, penetrating into the small intestine. Eating food has no effect on the absorption of the pharmaceutical product. The maximum content of the active substance in the blood is reached one to two hours after the ingestion of Amoxil. About a quarter of amoxicillin enters the bloodstream by binding to plasma proteins. The remainder penetrates into bone tissue, mucous membranes, phlegm, the fluid inside the eyes.
Indications for use Amoxil
The main indications for Amoxil's use are represented by various infectious lesions of organs and their systems, which are provoked by invasions of microorganisms that are sensitive to the described antibiotic drug. When using Amoxil, bacterial lesions of the following body structures can be treated:
- reproductive system;
- urinary system;
- soft tissues;
- respiratory system;
To increase the effectiveness of therapy for gastrointestinal tract diseases, a combination of Amoxil and Clarithromycin or Metronidazole is mainly used.
Amoxil has a number of contraindications, in which the use of the drug is strictly not recommended, since there is a possibility of causing significant damage to the body. The main contraindications to the use of Amoxil are the following conditions:
Personal intolerance to the components of the pharmacological drug, as well as other antibiotic drugs of the penicillin series. In case of excessive sensitivity to the cephalosporin series' antibiotics, it is necessary to take into account the likelihood of developing an allergic cross-type reaction.
It is forbidden to use Amoxil for infectious mononucleosis.
You can not take an antibiotic drug for lymphocytic leukemia.
Applications and doses Amoxil
The required duration of therapy and the frequency of use is determined by the attending physician. Amoxil It is not recommended to violate the attending specialist's prescriptions, since it is likely that side effects will develop if the dose is exceeded or an insufficient therapeutic effect if it is reduced.
Taking pills has no dependence on food. For moderate and mild diseases, the treatment regimen involves taking Amoxil 500-750mg 2 times/day. In chronic recurrent pathologies and in severe cases, it is supposed to take 3 g daily. The maximum daily dose is 6g.
Therapy should be continued for another 3 days after the disappearance of the symptomatic manifestations of the disease. Moderate and mild infections require a 7-day course of therapy. When infected with beta-hemolytic streptococcus, a 10-day course is required. Therapy of acute uncomplicated gonorrhea involves a single use of Amoxil at the rate of 1 g of the active ingredient, in combination with probenecid at the same dosage.
In the case of renal failure, the drug is prescribed, taking into account fluctuations in glomerular filtration and creatinine clearance values.
Children from 3 to 10 years old are required to take 750 mg, which are divided into 3 doses. At the age of 1 to 3 years, it is required to take 250 mg 2 times/day. In chronic diseases and severe pathologies, it is assumed that 60 mg/kg of the child's body weight is taken, the daily dose is divided into 3 doses. According to the dosage regimen for patients of the adult age group, children from 10 years old take Amoxil according to the dosage regimen.
For pregnant women and during lactation
If it is necessary to use Amoxil during gestation, it is required to assess the intended benefit to the mother in relation to the likely risks to the child. No teratogenic effect of the drug was found. The drug penetrates into breast milk in small concentrations; for this reason, it is required to stop feeding the baby with breast milk for the period of treatment with antibiotic medication.
Amoxil tablets are characterized by a low degree of toxicity, so they very rarely provoke adverse reactions from the body. Nevertheless, antibiotics of the penicillin series can stimulate the development of an allergic rash, which disappears without assistance immediately after stopping the course of treatment.
The manufacturer indicates such options for adverse reactions from the use of Amoxil:
- development of candidiasis of the mucous membranes and skin surface;
- circulatory and lymphatic systems: hemolytic anemia, leukopenia, thrombocytopenia, eosinophilia, increased risk of bleeding, increased prothrombin time;
- immune system: allergic manifestations, Quincke's edema, anaphylaxis, serum sickness;
- CNS: sleep disturbances, headaches, loss of coordination and consciousness, dizziness;
- organs of the gastrointestinal tract: appetite disorders, dyspeptic disorders, nausea, pain in the epigastric region, itching of the anus, staining of the teeth, darkening of the tongue, colitis of various types;
- from the liver: hepatitis, jaundice of the cholestatic variety, an increase in the amount of liver enzymes;
- skin and subcutaneous tissues: the appearance of the rash, itching, urticaria, erythema, the development of epidermal necrosis, dermatitis;
- urinary system: nephritis, crystalluria.
Most of the adverse reactions develop due to the use of the drug in high doses. Termination of the course of therapy leads to the normalization of the person's general condition and does not require special medical care. To prevent the development of pathological phenomena from the gastrointestinal tract organs, disorders of the digestive process, probiotics should be used simultaneously with the start of antibiotic therapy to maintain the balance of the intestinal microflora.